Terms offered: Spring , Fall , Spring Identifying pathways that restrict growth and cell proliferation in vivo. Terms offered: Spring , Fall , Spring Cell surface growth with emphasis on the unicellular eukaryote S. Terms offered: Spring , Fall , Spring Malignant transformation represents the endpoint of successive genetic lesions that confer uncontrolled proliferation and survival, unlimited replicative potential, and invasive growth. Terms offered: Spring , Fall , Spring Inheritance, chromatin structure, gene expression, and the organization of chromosomes in the nucleus.
Terms offered: Spring , Fall , Spring Review of current literature and discussion of current research. Current research focuses on regulation of energy metabolism and the effect of changes in energy metabolism induced by diet and exercise on age-associated functional decline of organisms. Terms offered: Spring , Fall , Spring Mechanisms underlying the establishment and maintenance of cellular organization in epithelia and other cell types. Terms offered: Spring , Fall , Spring The goal of our laboratory is to understand the key functions of telomeres and telomerase in tissue homeostasis, tumorigenesis, and aging.
To this end, we generate genetically engineered human pluripotent and adult stem cell models to measure telomere and telomerase function during cellular differentiation and tumor formation. Terms offered: Spring , Fall , Spring Research in our lab is focused on the cell biology of mammalian fertilization.
Our lab uses biophysical, biochemical, and molecular genetics methods to study sperm ion channels and transporters that regulate sperm motility, chemotaxis, and the acrosome reaction. A better understanding of these processes will eventually lead to the development of effective tools to control and preserve male fertility, improve the reproductive health of human population worldwide, and advance family planning.
Current research focuses on elucidating the molecular mechanisms of somatosensory mechanotransduction. Terms offered: Spring , Fall , Spring How chromosomes are reorganized during melosis to accomplish the pairing, recombinatin, and segregation leading up to successful gamete production. Terms offered: Spring , Spring , Spring Principles and practice of classical and modern genetic analysis as applied to eukaryotic organisms, including yeast, nematodes, , mice and humans; isolation and analysis of mutations; gene mapping; suppressor analysis; chromosome structure; control of gene expression; and developmental genetics.
Terms offered: Spring , Spring A graduate seminar class in which a group of students will closely examine recent computational methods in high-throughput sequencing followed by directly examining interesting biological applications thereof. Terms offered: Spring Introduction to algebraic statistics and probability, optimization, phylogenetic combinatorics, graphs and networks, polyhedral and metric geometry.
Terms offered: Spring , Fall , Spring Central to the aging process is the unfolding of the proteome. Specific areas under study include cellular responses to protein misfolding and coordination of these responses across an organism. Terms offered: Spring , Fall , Spring Biochemical and molecular genetic aspects of eukaryotic messenger RNA splicing and transposition, with an emphasis on as an experimental system. Terms offered: Spring , Fall , Spring Genes, gene products and molecular mechanisms that control cell types in the unicellular eukaryote.
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- Farther Up the Main (Coastal British Columbia Stories Book 7).
- Off Axis (Silicon Road).
Terms offered: Spring , Fall , Spring Gene regulation and developmental neurobiology. Terms offered: Spring , Fall , Spring Molecular and genetic approaches to the problem of how neurons develop, with emphasis on and.
Terms offered: Spring , Fall , Spring We study how genes control pattern formation during development and pattern modification during evolution. Terms offered: Spring , Fall , Spring This course focuses on understanding 1 how cellular aging is affected during gametogenesis, the developmental program that produces gametes for sexual reproduction and 2 how chromosome segregation is regulated during meiosis, the specialized cell division that generates gametes.
Terms offered: Spring , Fall , Spring Research focuses on use of statistical and computational approaches to study questions in human genetics and evolutionary biology. This includes, but is not limited to, studying 1 how different evolutionary processes such as mutation rate evolve across primates, 2 when key events such as introgression and adaptations occurred in human history, and 3 how we can leverage large-scale datasets to identify genetic variants related to human adaptation and disease. Terms offered: Spring , Fall , Spring Molecular and genetical analysis of sex determination and dosage compensation in the nematode.
Terms offered: Spring , Fall , Spring Evaluation of current research on choanoflagellates, sponges, and animal origins. Intended to complement ongoing research for graduate students. Terms offered: Spring , Fall , Spring Research review in genetics, genomics and development. We will explore how the detection of single particles DNA, RNA, proteins can help with understanding cellular organization and enzymatic processes dynamics and kinetics. Most of the experiments described will be drawn from the gene expression and nuclear organization literature.
In development a single cell goes through a series of repeated divisions and these cells read the program encoded in their DNA in order to become familiar cell types such as those found in muscle, liver, or our brains. The goal of our lab is to uncover the rules behind these decisions with the objective of predicting and manipulating developmental programs from just looking at DNA sequence. In order to reach this predictive understanding we combine physics, synthetic biology, and new technologies to query and control developmental decisions in real time at the single cell level in the fruit fly embryo.
Terms offered: Fall , Fall , Fall Current literature and research in gene regulation will be covered in research reports and reviews of the current literature and in discussion of current experiments in the field. Terms offered: Spring , Fall , Spring Biochemistry, cancer biology and virology, cell biology, computational biology, genetics, microbiology, molecular and cell physiology. Terms offered: Spring , Fall , Spring Recent developments in computational methods for genomics and their application for understanding the structure and function of genes encoded in completely sequenced genomes.
Terms offered: Fall , Spring , Fall Evolution of development mechanisms with a focus on the genes that regulate segmentation and regionalization of the body plan. Terms offered: Spring , Fall , Spring Comparative analysis of eukaryotic genomes to inform the origins and diversification of animals and plants. Terms offered: Spring , Fall , Spring The Roelink laboratory is interested in the mechanisms of embryonic induction, the phenomenon in which a group of cells changes the developmental fate of neighboring cells via the release of inducers.
Terms offered: Spring , Spring , Fall Discussions pertaining to the development of new genetic tools for archaeal model organisms with a particular emphasis on methane metabolizing archaea in order to characterize their physiology, evolution and metabolism. Terms offered: Spring , Fall , Spring The fundamental problem of comparative genomics: the determination of the origins and evolutionary history of the nucleotides in all extant genomes.
My work incorporates various aspects of genomics, including the reconstruction of ancestral genomes paleogenomics , the modeling of genome dynamics phylogenomics and systems biology , and the assignment of function of genome elements functional genomics and epigenomics. Terms offered: Spring , Fall , Spring This course will focus on mechanisms of gene control in vertebrate animals, particularly in the area of vertebrate development.
François Jacob set to work on eukaryotes
Amphibian egg formation, mesoderm induction, neural induction, and patterning of the nervous system at the molecular level. Control of transcription, post-transcriptional control of gene expression including control of RNA turnover and RNA localization. Terms offered: Spring , Fall , Spring Use of genetic, cell biological, and biochemical approaches in budding yeast to understand genome integrity, genome evolution, and most recently desiccation tolerance.
Terms offered: Spring , Spring , Spring Molecular and cellular analysis of the immune response emphasizing concepts and methodology. Innate immunity, pathogen sensors, antibodies and T cell receptors, lymphocyte activation, tolerance and selection. Antigen processing, T cell subtypes, and T regulatory cells. Terms offered: Spring , Fall , Spring This is an advanced seminar course which will consider current research questions and experimental approaches in molecular and cellular immunology.
Each registrant will present a minute research talk describing the problems they are studying, the approach they are taking, their preliminary data, and technical problems.
Longevity and anti-aging research: ‘Prime time for an impact on the globe’
Other course participants including basic immunology faculty will provide criticism and suggestions. Terms offered: Spring , Fall , Spring The TB field has entered a new era with the convergence of genetic tools, genome sequencing, bioinformatics, advanced imaging techniques, animal models of infection, and high-throughput assays that allow us to study this multi-faceted interaction between Mtb and its host.
We use all of these tools to probe the molecular and cellular events that enable M. Mycobacterium Tuberculosis Mtb : Read Less [-]. Terms offered: Spring , Fall , Spring Mechanisms of immune surveillance by T lymphocytes. Terms offered: Spring , Fall , Spring In this course we will discuss our research as well as recent literatures focusing on understanding of 1 How is homeostasis in the CNS regulated by innate immune functions of microglia? Programmed cell death during thymocyte differentiation.
Genes That Prolong Life | The Journals of Gerontology: Series A | Oxford Academic
Terms offered: Spring , Fall , Spring Molecular and biological basis for recognition by natural killer cells and T cells. Terms offered: Spring , Fall , Spring Molecular and cellular aspects of thymocyte differentiation. Role of transcription factors in B cell activation. Terms offered: Spring , Fall , Spring The mechanisms used by viruses to counteract the pressure of the immune system.
Terms offered: Spring , Fall , Spring Intersecting the fields of cancer biology, immunology, and epigenetics to strengthen our own immune defense mechanisms against our own cancers by reprogramming T cell function specifically within the tumor microenvironment.
Terms offered: Spring , Fall , Spring Innate immunity and innate control of adaptive immunity. Terms offered: Spring , Fall , Spring Role of innate host responses in defense against intracellular bacterial pathogens. Cellular and Developmental Neurobiology: Read Less [-]. Terms offered: Spring , Spring , Spring Advanced coverage of current research problems in systems-level neuroscience, and experimental and computational techniques used for these studies.
Circuit and Systems Neurobiology: Read Less [-]. Terms offered: Spring , Spring , Spring Molecular and cellular studies of nerve growth, axon guidance, synaptic formation, and synaptic plasticity using electrophysiological and optical imaging techniques. Terms offered: Spring , Fall , Spring Research in our laboratory focuses on understanding how neurons use biochemical pathways to integrate diverse types of information in order to adjust synaptic strength and modulate neuronal excitability, and how these interactions go awry in disease.
To investigate this we are taking a multi-disciplinary approach incorporating molecular, biochemical, imaging, and electrophysiological analyses in mouse and human cells. Terms offered: Spring , Fall , Spring Review of recent research in molecular mechanisms involved in intracellular and extracellular signaling in the nervous system. Terms offered: Spring , Fall , Spring Review of research in molecular and biophysical aspects of sensory transduction and electrical signaling in the nervous system. Prerequisites: Enrollment is restricted to students conducting research in the laboratory of the instructor, or requires consent of the instructor.
Molecular and Biophysical Neuroscience: Read Less [-]. Terms offered: Spring , Fall , Spring Research review in neurobiology. Review of recent optogenetic strategies for dissecting neural connectivity, function, and dysfunction in the rodent and primate brain. Terms offered: Spring , Fall , Spring Development and application of optical imaging methods for clearer, deeper, and faster imaging of biological tissue in vivo, including a critical review of the current research.
Terms offered: Spring , Fall , Spring The basic investigation of neural differentiation of stem cells, as well as the use of stem cells and gene delivery for neuroregeneration. Terms offered: Spring , Fall , Spring The molecular and cellular basis of taste perception in the model organism. Terms offered: Spring , Fall , Spring Drosophila mutants that have behavioral abnormalities to unravel new and basic features of nervous system structure and function. Terms offered: Spring , Fall , Spring Microcircuitry of the cerebral cortex that underlies sensory processing and adaptive behavior.
Terms offered: Spring , Fall , Spring How the cerebral cortex processes sensory input and stores information about the sensory world.
We focus on the rat's primary somatosensory S1 cortex. Terms offered: Spring , Fall , Spring Evaluation of current research in molecular mechanisms underlying diseases of the retina. Terms offered: Spring , Fall , Spring How neural activity affects the assembly of neural circuits.